A mathematical program to refine gene regulatory networks

Mathematical Modelling of Gene Regulatory Networks

Due to the fact that large amount of date about processes in living cells are being collected every day, it become necessary to use computers for data processing and analysis. Introducing computer technologies into biology new discipline has been develop, systems biology or computational biology. The aim of system biology is describing and understanding how parts of organism interact in one com...

A mathematical framework for describing and analysing gene regulatory networks.

This paper presents a mathematical framework for describing and analysing gene regulatory networks by autonomous differential equations. It represents an improvement on existing frameworks in that it may handle a wider range of gene regulatory mechanisms. Gene regulatory networks are frequently threshold-dominated, i.e. genes are activated only when the concentration of certain gene products li...

Understanding microRNA-mediated gene regulatory networks through mathematical modelling

The discovery of microRNAs (miRNAs) has added a new player to the regulation of gene expression. With the increasing number of molecular species involved in gene regulatory networks, it is hard to obtain an intuitive understanding of network dynamics. Mathematical modelling can help dissecting the role of miRNAs in gene regulatory networks, and we shall here review the most recent developments ...

Mathematical description of gene regulatory units.

Revealing the control mechanisms responsible for the cell's surprisingly well-organized functions should lead directly to a better understanding of how the cell adapts to extraordinarily changing environments. A general framework for describing models that can represent diverse biochemical regulatory functions systematically would help not only systematic interpretation of the various models pr...

Ee 6902 Mathematical Modeling of Gene Regulatory